Matching in hospital based case-control studies
نویسندگان
چکیده
منابع مشابه
Smoking prevalence in neighborhood and hospital controls: implications for hospital-based case-control studies.
It is widely believed that the prevalence of smoking among hospital patients is greater than that of the general population because many conditions for which patients are hospitalized are caused by or associated with smoking, and that this increased prevalence may bias results of case-control studies of tobacco-related diseases. For this reason, many authors have suggested excluding from the co...
متن کاملFlexible matching in case-control studies of gene-environment interactions.
Because of the lack of power of case-control study designs to detect gene-environment interactions, flexible matching has recently been proposed as a method of improving efficiency. In this paper, the authors consider a large-sample approximation method that allows estimation of the most efficient matching strategy when genotype and exposure are either independent or associated. The authors pro...
متن کاملFamily-Based Case–Control Studies
Case–control studies are used often in epidemiologic studies to investigate the association between disease and one or more risk factors. With increasing frequency, the set of risk factors being considered includes genotypes at one or more susceptibility, candidate, or marker loci (see Markers). The goals of association studies will differ, depending on the state of knowledge about a given dise...
متن کاملHospital visitors as controls in case-control studies.
OBJECTIVE Selecting controls is one of the most difficult tasks in the design of case-control studies. Hospital controls may be inadequate and random controls drawn from the base population may be unavailable. The aim was to assess the use of hospital visitors as controls in a case-control study on the association of organochlorinated compounds and other risk factors for breast cancer conducted...
متن کاملGenotype-based matching to correct for population stratification in large-scale case-control genetic association studies.
Genome-wide association studies are helping to dissect the etiology of complex diseases. Although case-control association tests are generally more powerful than family-based association tests, population stratification can lead to spurious disease-marker association or mask a true association. Several methods have been proposed to match cases and controls prior to genotyping, using family info...
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ژورنال
عنوان ژورنال: Annals of African Medicine
سال: 2016
ISSN: 1596-3519
DOI: 10.4103/1596-3519.158523